Northern Greece, including the regions of Macedonia and Thrace, boasts a long history of winemaking dating back thousands of years. The climate is continental, with cold winters and hot summers, but with significant variation depending on the specific location within the region.

Macedonia, in particular, is known for producing a range of red wines, including Xinomavro, the region's most important and widely planted grape. This grape is known for its tannins and acidity, and produces age-worthy, complex wines that are often compared to Nebbiolo from Italy's Piedmont region. Other popular red grape varieties in the region include the aromatic Limnio and the fruity Negoska.

In Thrace, the focus is on both red and white wines, with grape varieties including Assyrtiko, Chardonnay, Malagousia, Cabernet Sauvignon, and Merlot. The wines produced here are often more fruit-forward and approachable than those from Macedonia.

Overall, Northern Greece is a region in Greece with a rich winemaking tradition and a variety of unique grape varieties, producing wines with distinct character and complexity.